We all love a good drink, me included because often I’m hilarious when I’ve had a drink. However I’m seeing more and more of people unhappy with their progress or changes but out drinking every weekend or having ” a cheeky one” every other day.

Not only can alcohol be calorific, drinking regularly can also negatively impact fat loss, health, body composition, strength and overall aesthetic beauty, while negatively affecting the liver, pancreas and immune system. This is going to be a long one, so skip to those parts if you’re in a rush.

Depending on the overall state of your body, liver and health one big night out can totally halt your fat loss for 7-10 days in bad cases, meaning if you are out every weekend you have little to no chance of losing fat in the short term, and the long term isn’t even worth thinking about.

My point is that it is always about priorities – which do you want more? Going out and having fun is something we should all do for our own mental and physical health but when it’s a weekly thing, it will override any efforts you make in the gym and kitchen completely.

Think about it. Be smart, and accept that it will have an effect on your results. Don’t let things get you down if you’re not progressing at the speed you like if this is a variable that may be out of place for you.

I don’t want you guys not going out and having fun, you all need to have lives. What I do want, though, is for you to understand the other side of the coin before you get upset about your body composition, and before you send your coaches an unhappy email check-in complaining about slow changes and no progress. So here we go…

How Alcohol Affects the Brain

WHAT HAPPENS INSIDE THE BRAIN?

The brain’s structure is complex. It includes multiple systems that interact to support all of your body’s functions—from thinking to breathing and moving.

These multiple brain systems communicate with each other through about a trillion tiny nerve cells called neurons. Neurons in the brain translate information into electrical and chemical signals the brain can understand. They also send messages from the brain to the rest of the body.

Chemicals called neurotransmitters carry messages between the neurons. Neurotransmitters can be very powerful. Depending on the type and the amount of neurotransmitter, these chemicals can either intensify or minimize your body’s responses, your feelings, and your mood. The brain works to balance the neurotransmitters that speed things up with the ones that slow things down to keep your body operating at the right pace.

Alcohol can slow the pace of communication between neurotransmitters in the brain.

DISCOVERING THE BRAIN CHANGES

There still is much we do not understand about how the brain works and how alcohol affects it. Researchers are constantly discovering more about how alcohol interrupts communication pathways in the brain and changes brain structure, and the resulting effects on behavior and functioning.

DEFINING THE BRAIN CHANGES

Using brain imaging and psychological tests, researchers have identified the regions of the brain most vulnerable to alcohol’s effects.

These include:

  • CEREBELLUM – This area controls motor coordination. Damage to the cerebellum results in a loss of balance and stumbling, and also may affect cognitive functions such as memory and emotional response.
  • LIMBIC SYSTEM – This complex brain system monitors a variety of tasks including memory and emotion. Damage to this area impairs each of these functions.
  • CEREBRAL CORTEX – Our abilities to think, plan, behave intelligently, and interact socially stem from this brain region. In addition, this area connects the brain to the rest of the nervous system. Changes and damage to this area impair the ability to solve problems, remember, and learn.

ALCOHOL SHRINKS AND DISTURBS BRAIN TISSUE

Heavy alcohol consumption—even on a single occasion—can throw the delicate balance of neurotransmitters off course. Alcohol can cause your neurotransmitters to relay information too slowly, so you feel extremely drowsy. Alcohol-related disruptions to the neurotransmitter balance also can trigger mood and behavioral changes, including depression, agitation, memory loss, and even seizures.

Source: Thanos, Wang and Volkow (2008)

Long-term, heavy drinking causes alterations in the neurons, such as reductions in the size of brain cells. As a result of these and other changes, brain mass shrinks and the brain’s inner cavity grows bigger. These changes may affect a wide range of abilities, including motor coordination; temperature regulation; sleep; mood; and various cognitive functions, including learning and memory.

One neurotransmitter particularly susceptible to even small amounts of alcohol is called glutamate. Among other things, glutamate affects memory. Researchers believe that alcohol interferes with glutamate action, and this may be what causes some people to temporarily “black out,” or forget much of what happened during a night of heavy drinking.

Alcohol also causes an increased release of serotonin, another neurotransmitter, which helps regulate emotional expression, and endorphins, which are natural substances that may spark feelings of relaxation and euphoria as intoxication sets in. Researchers now understand that the brain tries to compensate for these disruptions. Neurotransmitters adapt to create balance in the brain despite the presence of alcohol. But making these adaptations can have negative results, including building alcohol tolerance, developing alcohol dependence, and experiencing alcohol withdrawal symptoms.

WHAT FACTORS MAKE A DIFFERENCE?

Different people react differently to alcohol. That is because a variety of factors can influence your brain’s response to alcohol. These factors include:

  • HOW MUCH AND HOW OFTEN YOU DRINK – The more you drink, the more vulnerable your brain is.
  • YOUR GENETIC BACKGROUND AND FAMILY HISTORY OF ALCOHOLISM – Certain ethnic populations can have stronger reactions to alcohol, and children of alcoholics are more likely to become alcoholics themselves.
  • YOUR PHYSICAL HEALTH – If you have liver or nutrition problems, the effects of alcohol will take longer to wear off.

ARE BRAIN PROBLEMS REVERSIBLE?

Abstaining from alcohol over several months to a year may allow structural brain changes to partially correct. Abstinence also can help reverse negative effects on thinking skills, including problem-solving, memory, and attention.

OTHER ALCOHOL-RELATED BRAIN CONDITIONS

LIVER DAMAGE THAT AFFECTS THE BRAIN

Not only does alcoholic liver disease affect liver function itself, it also damages the brain. The liver breaks down alcohol—and the toxins it releases. During this process, alcohol’s byproducts damage liver cells. These damaged liver cells no longer function as well as they should and allow too much of these toxic substances, ammonia and manganese in particular, to travel to the brain.These substances proceed to damage brain cells, causing a serious and potentially fatal brain disorder known as hepatic encephalopathy.

Hepatic encephalopathy causes a range of problems, from less severe to fatal. These problems can include:

  • Sleep disturbances
  • Mood and personality changes
  • Anxiety
  • Depression
  • Shortened attention span
  • Coordination problems, including asterixis, which results in hand shaking or flapping
  • Coma
  • Death

Doctors can help treat hepatic encephalopathy with compounds that lower blood ammonia concentrations and with devices that help remove harmful toxins from the blood. In some cases, people suffering from hepatic encephalopathy require a liver transplant, which generally helps improve brain function.

FETAL ALCOHOL SPECTRUM DISORDERS

Alcohol can affect the brain at any stage of development—even before birth. Fetal alcohol spectrum disorders are the full range of physical, learning, and behavioral problems, and other birth defects that result from prenatal alcohol exposure. The most serious of these disorders, fetal alcohol syndrome (FAS), is characterized by abnormal facial features and is usually associated with severe reductions in brain function and overall growth. FAS is the leading preventable birth defect associated with mental and behavioral impairment in the United States today. The brains of children with FAS are smaller than normal and contain fewer cells, including neurons. These deficiencies result in life-long learning and behavioral problems. Current research is investigating whether the brain function of children and adults with FAS can be improved with complex rehabilitative training, dietary supplements, or medications.

How Alcohol Affects the Heart

ALCOHOLIC CARDIOMYOPATHY

Long-term heavy drinking weakens the heart muscle, causing a condition called alcoholic cardiomyopathy. A weakened heart droops and stretches and cannot contract effectively. As a result, it cannot pump enough blood to sufficiently nourish the organs. In some cases, this blood flow shortage causes severe damage to organs and tissues. Symptoms of cardiomyopathy include shortness of breath and other breathing difficulties, fatigue, swollen legs and feet, and irregular heartbeat. It can even lead to heart failure.

ARRHYTHMIAS

Both binge drinking and long-term drinking can affect how quickly a heart beats.The heart depends on an internal pacemaker system to keep it pumping consistently and at the right speed. Alcohol disturbs this pacemaker system and causes the heart to beat too rapidly, or irregularly. These heart rate abnormalities are called arrhythmias. Two types of alcohol induced arrhythmias are:

  • ATRIAL FIBRILLATION – In this form of arrhythmia, the heart’s upper, or atrial, chambers shudder weakly but do not contract. Blood can collect and even clot in these upper chambers. If a blood clot travels from the heart to the brain, a stroke can occur; if it travels to other organs such as the lungs, an embolism, or blood vessel blockage, occurs.
  • VENTRICULAR TACHYCARDIA – This form of arrhythmia occurs in the heart’s lower, or ventricular, chambers. Electrical signals travel throughout the heart’s muscles, triggering contractions that keep blood flowing at the right pace. Alcohol-induced damage to heart muscle cells can cause these electrical impulses to circle through the ventricle too many times, causing too many contractions. The heart beats too quickly, and so does not fill up with enough blood between each beat. As a result, the rest of the body does not get enough blood. Ventricular tachycardia causes dizziness, lightheadedness, unconsciousness, cardiac arrest, and even sudden death. Drinking to excess on a particular occasion, especially when you generally don’t drink, can trigger either of these irregularities. In these cases, the problem is nicknamed “holiday heart syndrome,” because people who don’t usually drink may consume too much alcohol at parties during the holiday season. Over the long-term, chronic drinking changes the course of electrical impulses that drive the heart’s beating, which creates arrhythmia.

STROKES

A stroke occurs when blood cannot reach the brain. In about 80 percent of strokes, a blood clot prevents blood flow to the brain. These are called ischemic strokes. Sometimes, blood accumulates in the brain, or in the spaces surrounding it. This causes hemorrhagic strokes.

Both binge drinking and long-term heavy drinking can lead to strokes even in people without coronary heart disease. Recent studies show that people who binge drink are about 56 percent more likely than people who never binge drink to suffer an ischemic stroke over 10 years. Binge drinkers also are about 39 percent more likely to suffer any type of stroke than people who never binge drink.

In addition, alcohol exacerbates the problems that often lead to strokes, including hypertension, arrhythmias, and cardiomyopathy.

HYPERTENSION

Chronic alcohol use, as well as binge drinking, can cause high blood pressure, or hypertension. Your blood pressure is a measurement of the pressure your heart creates as it beats, and the pressure inside your veins and arteries. Healthy blood vessels stretch like elastic as the heart pumps blood through them. Hypertension develops when the blood vessels stiffen, making them less flexible. Heavy alcohol consumption triggers the release of certain stress hormones that in turn constrict blood vessels.This elevates blood pressure. In addition, alcohol may affect the function of the muscles within the blood vessels, causing them to constrict and elevate blood pressure.

How Alcohol Affects the Liver

Your liver works hard to keep your body productive and healthy. It stores energy and nutrients. It generates proteins and enzymes your body uses to function and ward off disease. It also rids your body of substances that can be dangerous—including alcohol.

The liver breaks down most of the alcohol a person consumes. But the process of breaking alcohol down generates toxins even more harmful than alcohol itself. These by-products damage liver cells, promote inflammation, and weaken the body’s natural defenses. Eventually, these problems can disrupt the body’s metabolism and impair the function of other organs.

Because the liver plays such a vital role in alcohol detoxification, it is especially vulnerable to damage from excessive alcohol.

KNOW THE CONSEQUENCES

Heavy drinking—even for just a few days at a time—can cause fat to build up in the liver. This condition, called steatosis, or fatty liver, is the earliest stage of alcoholic liver disease and the most common alcohol-induced liver disorder. The excessive fat makes it more difficult for the liver to operate and leaves it open to developing dangerous inflammations, like alcoholic hepatitis.

For some, alcoholic hepatitis does not present obvious symptoms. For others, though, alcoholic hepatitis can cause fever, nausea, appetite loss, abdominal pain, and even mental confusion. As it increases in severity, alcoholic hepatitis dangerously enlarges the liver, and causes jaundice, excessive bleeding, and clotting difficulties.

Another liver condition associated with heavy drinking is fibrosis, which causes scar tissue to build up in the liver. Alcohol alters the chemicals in the liver needed to break down and remove this scar tissue. As a result, liver function suffers.

If you continue to drink, this excessive scar tissue builds up and creates a condition called cirrhosis, which is a slow deterioration of the liver. Cirrhosis prevents the liver from performing critical functions, including managing infections, removing harmful substances from the blood, and absorbing nutrients.

A variety of complications, including jaundice, insulin resistance and type 2 diabetes, and even liver cancer, can result as cirrhosis weakens liver function.

Risk factors ranging from genetics and gender, to alcohol accessibility, social customs around drinking, and even diet can affect a person’s individual susceptibility to alcoholic liver disease. Statistics show that about one in five heavy drinkers will develop alcoholic hepatitis, while one in four will develop cirrhosis.

How Alcohol Affects the Pancreas

The pancreas plays an important role in food digestion and its conversion into fuel to power your body. It sends enzymes into the small intestine to digest carbohydrates, proteins, and fat. It also secretes insulin and glucagon, hormones that regulate the process of utilizing glucose, the body’s main source of energy. Insulin and glucagon control glucose levels, which helps all cells use the energy glucose provides. Insulin also ensures that extra glucose gets stored away as either glycogen or fat.

When you drink, alcohol damages pancreatic cells and influences metabolic processes involving insulin. This process leaves the pancreas open to dangerous inflammations.

A pancreas unaffected by alcohol sends enzymes out to the small intestine to metabolize food. Alcohol jumbles this process. It causes the pancreas to secrete its digestive juices internally, rather than sending the enzymes to the small intestine. These enzymes, as well as acetaldehyde—a substance produced from metabolizing, or breaking down the alcohol—are harmful to the pancreas. If you consume alcohol excessively over a long time, this continued process can cause inflammation, as well as swelling of tissues and blood vessels.

This inflammation is called pancreatitis, and it prevents the pancreas from working properly. Pancreatitis occurs as a sudden attack, called acute pancreatitis. As excessive drinking continues, the inflammation can become constant. This condition is known as chronic pancreatitis.

Pancreatitis is also a risk factor for the development of pancreatic cancer.

A heavy drinker may not be able to detect the build-up of pancreatic damage until the problems set off an attack.

An acute pancreatic attack causes symptoms including:

  • Abdominal pain, which may radiate up the back
  • Nausea and vomiting
  • Fever
  • Rapid heart rate
  • Diarrhea
  • Sweating

Chronic pancreatitis causes these symptoms as well as severe abdominal pain, significant reduction in pancreatic function and digestion, and blood sugar problems. Chronic pancreatitis can slowly destroy the pancreas and lead to diabetes or even death.

While a single drinking binge will not automatically lead to pancreatitis, the risk of developing the disease increases as excessive drinking continues over time.

These risks apply to all heavy drinkers, but only about 5 percent of people with alcohol dependence develop pancreatitis. Some people are more susceptible to the disease than others, but researchers have not yet identified exactly what environmental and genetic factors play the biggest role.

Does Alcohol Increase Cancer Risk?

Genetics, environment, and lifestyle habits can all heighten your risk of getting cancer. We can’t do anything to change our genes, and we often can’t do much to change our environment. But lifestyle habits are a different story.S

Source: Cancer Research UK

Drinking too much alcohol is one lifestyle habit that can increase your risk of developing certain cancers. This does not mean that anyone who drinks too much will develop cancer. But numerous studies do show the more you drink, the more you increase your chances of developing certain types of cancer.

For example, a group of Italy-based scientists reviewed more than 200 studies examining alcohol’s impact on cancer risk.The collective results of these studies clearly demonstrate that the more you drink, the higher your risk for developing a variety of cancers.The National Cancer Institute identifies alcohol as a risk factor for the following types of cancer:

  • Mouth
  • Esophagus
  • Pharynx
  • Larynx
  • Liver
  • Breast

At least 7 out of 10 people with mouth cancer drink heavily. Drinking five or more drinks per day can also increase your risk of developing other types of cancers, including colon or rectal cancer. In fact, summary estimates from the recent World Cancer Research Fund report indicate that women who drink five standard alcohol drinks each day have about 1.2 times the risk of developing colon or rectal cancer than women who do not drink at all.

People who drink are also more likely to smoke, and the combination increases the risk significantly. Smoking alone is a known risk factor for some cancers. But smoking and drinking together intensifies the cancer-causing properties of each substance. The overall effect poses an even greater risk.

The risk of throat and mouth cancers is especially high because alcohol and tobacco both come in direct contact with those areas. Overall, people who drink and smoke are 15 times more likely to develop cancers of the mouth and throat than nondrinkers and nonsmokers. In addition, recent studies estimate that alcohol and tobacco together are responsible for:

  • 80 percent of throat and mouth cancer in men
  • 65 percent of throat and mouth cancer in women
  • 80 percent of esophageal squamous cell carcinoma, a type of esophagus cancer
  • 25 to 30 percent of all liver cancers

WOMEN AND CANCER

One recent, groundbreaking study followed the drinking habits of 1.2 million middle-aged women over 7 years. The study found that alcohol increases women’s chances of developing cancers of the breast, mouth, throat, rectum, liver, and oesophagus. The researchers link alcohol to about 13 percent of these cancer cases.

In addition, the study concluded that cancer risk increases no matter how little or what kind of alcohol a woman drinks. Even one drink a day can raise risk, and it continues to rise with each additional drink. While men did not participate in this study, the researchers believe this risk is likely similar for men.

This study also attributes about 11 percent of all breast cancer cases to alcohol. That means that of the 250,000 breast cancer cases diagnosed in the United States in 2008, about 27,000 may stem from alcohol.

Scientists are still trying to figure out exactly how and why alcohol can promote cancer. There are a variety of possible explanations.

One explanation is that alcohol itself is not the primary trigger for cancer.We know that metabolizing, or breaking down, alcohol results in harmful toxins in the body. One of these toxins is called acetylaldehyde. Acetylaldehyde damages the genetic material in cells—and renders the cells incapable of repairing the damage. It also causes cells to grow too quickly, which makes conditions ripe for genetic changes and mistakes. Cancer can develop more easily in cells with damaged genetic material.

In addition, recent animal studies have shown that as cells try to break down alcohol, they cause the body to produce additional amounts of a protein called vascular endothelial growth factor (VEGF). VEGF promotes the growth of blood vessels and organ tissue. But, the flip side of having too much VEGF is that it allows blood vessels to grow in cancer cells that would die on their own. This allows the cancer cells to develop into tumors.

We also know that alcohol can damage the liver, causing cirrhosis. Cirrhosis results when too much scar tissue builds up within the liver and leaves it unable to perform its vital functions. One of the many complications that can result from cirrhosis is liver cancer.

Hormones may be the link between alcohol and breast cancer. Alcohol can increase the amounts of some hormones in the body, including estrogen. An excess of estrogen may lead to breast cancer.

Finally, genetics may play a role in preventing some heavy drinkers from developing cancer. A European research team examined 9,000 people with similar lifestyle habits to determine why some of them developed mouth and throat cancers, and some did not. Of the participants who were heavy drinkers, those who did not develop cancers had a particular genetic alteration that enabled them to break down alcohol about 100 times faster than in those without it. The study suggested that this gene is the reason why some people are less likely to develop cancer in response to heavy drinking.

How Alcohol Affects the Immune System

Germs and bacteria surround us everywhere. Luckily, our immune system is designed to protect our bodies from the scores of foreign substances that can make us sick. Drinking too much alcohol weakens the immune system, making your body a much easier target for disease. Understanding the effect alcohol can have on your immune system can inform the decisions you make about drinking alcohol.

Your immune system is often compared to an army. This army defends your body from infection and disease. Your skin and the mucous that lines your respiratory and gastrointestinal tracts help block bacteria from entering or staying in your body. If foreign substances somehow make it through these barriers, your immune system kicks into gear with two defensive systems: innate and adaptive.

The innate system exists in your body before you are exposed to foreign substances like bacteria, viruses, fungi, or parasites. These substances, which are called antigens, can invade your body and make you sick. The components of the innate system include:

  • WHITE BLOOD CELLS – White blood cells form your first line of defense against infection.They surround and swallow foreign bodies quickly.
  • NATURAL KILLER (NK) CELLS – Natural Killers are special white blood cells that detect and destroy cells infected with cancer or viruses.
  • CYTOKINES – White blood cells send out these chemical messengers directly to an infected site. Cytokines trigger inflammatory responses, like dilating blood vessels and increasing blood flow to the affected area. They also call on more white blood cells to swarm an infected area.

The adaptive system kicks in after you are exposed to an infection for the first time. The next time you encounter the same infection, your adaptive system fights it off even faster and more efficiently than the first time. The components of the adaptive system include:

  • T-LYMPHOCYTE CELLS – T-cells reinforce the work of white blood cells by targeting individual foreign substances.T-cells can identify and destroy a vast array of bacteria and viruses.They can also kill infected cells and secrete cytokines.
  • B-LYMPHOCYTE CELLS – B-cells produce antibodies that fight off harmful substances by sticking to them and making them stand out to other immune cells.
  • ANTIBODIES – After B-cells encounter antigens, they produce antibodies.These are proteins that target specific antigens and then remember how to combat the antigen.

Alcohol suppresses both the innate and the adaptive immune systems. Chronic alcohol use reduces the ability of white blood cells to effectively engulf and swallow harmful bacteria. Excessive drinking also disrupts the production of cytokines, causing your body to either produce too much or not enough of these chemical messengers. An abundance of cytokines can damage your tissues, whereas a lack of cytokines leaves you open to infection.

Chronic alcohol use also suppresses the development of T-cells and may impair the ability of NK cells to attack tumor cells. This reduced function makes you more vulnerable to bacteria and viruses, and less capable of destroying cancerous cells.

With a compromised immune system, chronic drinkers are more liable to contract diseases like pneumonia and tuberculosis than people who do not drink too much. There is also data linking alcohol’s damage to the immune system with an increased susceptibility to contracting HIV infection. HIV develops faster in chronic drinkers who already have the virus.

Drinking a lot on a single occasion also can compromise your immune system. Drinking to intoxication can slow your body’s ability to produce cytokines that ward off infections by causing inflammations.Without these inflammatory responses, your body’s ability to defend itself against bacteria is significantly reduced. A recent study shows that slower inflammatory cytokine production can reduce your ability to fight off infections for up to 24 hours after getting drunk.

So here it is. It’s a lengthy one, if you read the whole lot and you feel like you need a drink to process, grab fresh lime and soda instead, then give me a shout. I’d like to hear your feedback and questions.